Corpse Killer is a game released for the Sega CD, Sega CD 32X, 3DO, Sega Saturn, Windows 95 and Macintosh computers that features live action full motion video in a format similar to other games developed by Digital Pictures. The quality of the full motion video on the Sega CD version is less than that of the others. Also, after the release of the Sega CD version, Digital Pictures created an option to have English subtitles during the full motion video as critics had complained that it was difficult to understand what the driver was saying in the Sega CD and Sega 32X versions. Corpse Killer was the first CD game released for the Sega 32X.
Footage from the game was later recycled for the 2003 film Game Over.
An unnamed United States Marine is airdropped onto a tropical island on a top secret mission to stop the evil Dr. Hellman, who plans to release his army of zombies on the world. He is bitten by a zombie and also meets an attractive female reporter and a Rastafarian male driver. Four of the marine lieutenant's comrades are captured by Hellman and turned into zombies. To rescue them, the lieutenant infiltrates Hellman's compound and shoots each of them with bullets coated with extract from Datura plants, which can turn freshly created zombies back into humans.
Most of the gameplay is similar to other shooting full motion video games such as Lethal Enforcers. The player moves through the jungle shooting various zombies, collecting better ammunition (to prepare for a raid on Hellman's compound) and medicine to recover health.